Kisspeptin-10 5mg

Kisspeptin-10 5mg

$59.99

Kisspeptin-10 is a synthetic decapeptide derived from the endogenous KISS1 gene peptide family, known for its central role in regulating the hypothalamic–pituitary–gonadal (HPG) axis. As a potent stimulator of gonadotropin-releasing hormone (GnRH) neurons, Kisspeptin-10 has become a key research tool for scientists studying reproductive endocrinology, puberty initiation, and fertility-related signaling pathways.

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Description

Kisspeptin-10 is a synthetic decapeptide derived from the endogenous KISS1 gene peptide family, known for its central role in regulating the hypothalamic–pituitary–gonadal (HPG) axis. As a potent stimulator of gonadotropin-releasing hormone (GnRH) neurons, Kisspeptin-10 has become a key research tool for scientists studying reproductive endocrinology, puberty initiation, and fertility-related signaling pathways.

Key Research Areas

  • Reproductive Hormone Regulation: Supports studies exploring GnRH release, luteinizing hormone (LH) modulation, and downstream endocrine responses.

  • Fertility & Pubertal Development: Extensively used in models examining delayed puberty, infertility, and sex-hormone feedback mechanisms.

  • Metabolic–Endocrine Interactions: Emerging interest in the peptide’s potential connection to energy balance, body weight, and metabolic signaling.

  • Neuroscience Applications: Useful for examining how kisspeptin signaling influences mood, behavior, and neural communication in the limbic system.

Specifications

  • Peptide Name: Kisspeptin-10

  • Quantity: 5 mg

  • Form: Lyophilized powder

  • Grade: ≥98% purity, research-only

  • Storage: 2–9°C; protect from prolonged light and heat exposure

Intended Use
For laboratory research only. Not for human consumption, clinical use, or veterinary application.

Additional information

Benefits

• Primary role: Powerful natural stimulator of gonadotropin-releasing hormone (GnRH) release from the hypothalamus.
• Main physiological effects:
• Strongly triggers the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.
• LH surge is typically much larger than FSH response.
• Established and potential benefits:
• Restores LH/FSH pulsatility in patients with hypothalamic amenorrhea (HA) and functional hypogonadism.
• Induces robust testosterone production in men with low testosterone due to hypothalamic suppression.
• Triggers ovulation in women with hypothalamic amenorrhea (used in IVF and fertility treatment protocols).
• May reverse hypogonadotropic hypogonadism without the need for long-term hCG or testosterone replacement.
• Causes very rapid (within minutes) and dose-dependent rises in LH and testosterone (clinical studies show effects within 30–90 minutes of IV or SC injection).
• Does not directly desensitize GnRH neurons (unlike continuous GnRH exposure), so it can be given repeatedly without losing efficacy.
• Preserves or restores natural pulsatile gonadotropin secretion, maintaining fertility and testicular/ovarian function.
• Avoids supraphysiological estrogen levels seen with hCG or SERMs in men (less gynecomastia risk).
• Potential future treatment for delayed puberty, PCOS-related infertility, and certain cases of low libido linked to low kisspeptin signaling.
• May improve mood, energy, and sexual function by restoring physiological testosterone and estradiol levels.
• Research / off-label use highlights:
Research / off-label use highlights:
• Successfully used twice-weekly (IV or SC) in men to normalize testosterone levels after years of anabolic steroid-induced suppression.
• Single injections trigger ovulation in women undergoing IVF, potentially replacing hCG trigger shots with fewer side effects.
• Currently in clinical trials for hypogonadism, infertility, and as an alternative to traditional TRT.
• Side effects / safety profile so far:
• Generally well tolerated in studies.
• Most common: transient flushing, warmth, or mild headache shortly after injection.
• No significant suppression of the HPG axis observed with intermittent dosing.

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