ARA-290 (Cibinetide): Research Overview and Identifiers
Quick Answer
ARA-290 (cibinetide) is an 11-residue peptide, pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser, derived from the helix B surface of erythropoietin. Formula C51H84N16O21, molecular weight 1257.3 g/mol, CAS 1208243-50-8. It was designed to bind the innate repair receptor (EPOR/CD131) without erythropoietic activity, and is studied in innate-repair-receptor signaling, cytoprotection assays and inflammatory-pathway research.
Key Takeaways
- 11 residues starting with pyroglutamate.
- C51H84N16O21, 1257.3 g/mol, CAS 1208243-50-8.
- Derived from erythropoietin’s helix B surface.
- Targets the innate repair receptor rather than the classical EPO receptor dimer.
Identifiers
| Field | Value |
|---|---|
| Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Other names | Cibinetide, helix B surface peptide |
| Molecular formula | C51H84N16O21 |
| Molecular weight | 1257.3 g/mol |
| CAS number | 1208243-50-8 |
| Form | Lyophilized solid, sealed vial |
Separating Two Erythropoietin Pathways
Erythropoietin signals through two receptor arrangements: a homodimer of the EPO receptor, and a heteromer of the EPO receptor with CD131, often called the innate repair receptor. ARA-290 reproduces a small surface region of erythropoietin that engages the second arrangement, which lets researchers study that pathway on its own.
Research Areas
- Innate repair receptor (EPOR/CD131) signaling
- Cytoprotection assays
- Inflammatory-pathway research
Storage of the Sealed Vial
The compound ships as a lyophilized (freeze-dried) solid in a sealed vial labelled with its lot number. Store sealed vials as stated on the label, protected from light and moisture; see our storage and handling guide for temperature ranges.
Documentation
A certificate for this compound is not yet in the COA library; it is available on request for the current lot. See how to read a COA.
Frequently Asked Questions
What is ARA-290?
ARA-290 (cibinetide) is an 11-residue peptide from the helix B surface of erythropoietin, studied in innate-repair-receptor signaling.
What is the molecular weight of ARA-290?
ARA-290 (C51H84N16O21) has a molecular weight of 1257.3 g/mol.
What is the CAS number of ARA-290?
The CAS number of ARA-290 is 1208243-50-8.
Sold for in-vitro laboratory research only. Not for human or animal use and not for diagnostic or therapeutic procedures. Nothing here describes or suggests use in people.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
