Kisspeptin-10: Research Overview, Structure and Identifiers
Quick Answer
Kisspeptin-10 is the C-terminal ten-residue fragment of kisspeptin, the protein encoded by the KISS1 gene: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. It is the shortest form that still fully activates the kisspeptin receptor (KISS1R, also called GPR54). Formula C63H83N17O14, molecular weight 1302.4 g/mol, CAS 374675-21-5. It is used in KISS1R binding and signaling assays, GnRH-neuron research and reproductive-axis endocrinology.
Key Takeaways
- Ten residues with a C-terminal amide.
- C63H83N17O14, 1302.4 g/mol, CAS 374675-21-5.
- The minimal fully active fragment at KISS1R (GPR54).
- Also known as metastin (45-54).
Identifiers
| Field | Value |
|---|---|
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Other names | Metastin (45-54), KP-10 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.4 g/mol |
| CAS number | 374675-21-5 |
| Form | Lyophilized solid, sealed vial |
From KISS1 to Kisspeptin-10
The KISS1 gene produces a 145-residue precursor that is cut into kisspeptins of different lengths (54, 14, 13 and 10 residues). All share the same C-terminal RF-amide motif that binds KISS1R. The 54-residue form was first named metastin; kisspeptin-10 is its last ten residues, which is why it is also written as metastin (45-54).
Research Areas
- KISS1R (GPR54) binding and signaling
- GnRH-neuron research
- Reproductive-axis endocrinology
It is often studied alongside the LH/CG-receptor agonist HCG and in multi-pathway sets such as the Kisspeptin-10 + NAD+ + Glutathione research bundle.
Storage of the Sealed Vial
All of these compounds ship as lyophilized (freeze-dried) solids in sealed vials. Store sealed vials as stated on the label, protected from light and moisture, and see our storage and handling guide for temperature ranges. Each vial is labelled with its lot number, which ties it to its certificate.
Analytical Verification and Documentation
Each lot is tested by Testides, an independent laboratory, for HPLC purity and content. Certificates are published with their report numbers so they can be checked against the lab’s own record:
New to certificates? Our guide on how to read a COA walks through each field.
Frequently Asked Questions
What is Kisspeptin-10?
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin and an agonist at the kisspeptin receptor KISS1R (GPR54), used in reproductive-axis signaling research.
What is the molecular weight of Kisspeptin-10?
Kisspeptin-10 (C63H83N17O14) has a molecular weight of 1302.4 g/mol.
What is the CAS number of Kisspeptin-10?
The CAS number of Kisspeptin-10 is 374675-21-5.
What is the difference between kisspeptin-10 and kisspeptin-54?
They come from the same precursor and share the C-terminal receptor-binding motif. Kisspeptin-54 is the full 54-residue form; kisspeptin-10 is its last ten residues.
All compounds discussed are sold for in-vitro laboratory research only. They are not for human or animal use and not for diagnostic or therapeutic procedures. Nothing here describes or suggests use in people.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
