SS-31 (Elamipretide): Research Overview and Identifiers
Quick Answer
SS-31 (elamipretide, MTP-131) is a synthetic, cell-permeable tetrapeptide of the Szeto-Schiller family, D-Arg-Dmt-Lys-Phe-NH2. Formula C32H49N9O5, molecular weight 639.8 g/mol, CAS 736992-21-5. It binds cardiolipin in the inner mitochondrial membrane and is studied in mitochondrial membrane-potential and reactive-oxygen-species research.
Key Takeaways
- Four residues: D-Arg, 2′,6′-dimethyltyrosine (Dmt), Lys and Phe-amide.
- C32H49N9O5, 639.8 g/mol, CAS 736992-21-5.
- Binds cardiolipin, a phospholipid of the inner mitochondrial membrane.
- Often studied alongside MOTS-c and NAD+.
Identifiers
| Field | Value |
|---|---|
| Sequence | D-Arg-Dmt-Lys-Phe-NH2 |
| Other names | Elamipretide, MTP-131, Bendavia |
| Molecular formula | C32H49N9O5 |
| Molecular weight | 639.8 g/mol |
| CAS number | 736992-21-5 |
| Form | Lyophilized solid, sealed vial |
Structure and Target
The alternating aromatic and basic residues give SS-31 a positive charge and let it cross cell membranes. It concentrates at the inner mitochondrial membrane, where it associates with cardiolipin, the lipid that organizes the electron-transport complexes and cristae.
Research Areas
- Mitochondrial membrane potential
- Reactive-oxygen-species assays on isolated mitochondria
- Cristae structure and electron-transport research
See SS-31 vs MOTS-c and the MOTS-c overview. Sets include the NAD+ + MOTS-c + SS-31 bundle.
Storage of the Sealed Vial
The compound ships as a lyophilized (freeze-dried) solid in a sealed vial labelled with its lot number. Store sealed vials as stated on the label, protected from light and moisture; see our storage and handling guide for temperature ranges.
Analytical Verification and Documentation
Each lot is tested by Testides, an independent laboratory, for HPLC purity and content, and the certificate is published with its report number so it can be checked against the lab’s record: SS-31 10 mg certificate. New to certificates? Read how to read a COA.
Frequently Asked Questions
What is SS-31?
SS-31 (elamipretide) is a cell-permeable tetrapeptide, D-Arg-Dmt-Lys-Phe-NH2, that binds cardiolipin in the inner mitochondrial membrane.
What is the molecular weight of SS-31?
SS-31 (C32H49N9O5) has a molecular weight of 639.8 g/mol.
What is the CAS number of SS-31?
The CAS number of SS-31 is 736992-21-5.
Is SS-31 the same as elamipretide?
Yes. SS-31, elamipretide and MTP-131 are names for the same tetrapeptide.
Sold for in-vitro laboratory research only. Not for human or animal use and not for diagnostic or therapeutic procedures. Nothing here describes or suggests use in people.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
