MOTS-c: Mitochondrial-Derived Peptide Research Overview
Quick Answer
MOTS-c is a 16-residue peptide (MRWQEMGYIFYPRKLR) encoded by a short open reading frame inside the mitochondrial 12S rRNA gene, which makes it one of the few known mitochondrial-derived peptides. Formula C101H152N28O22S2, molecular weight 2174.6 g/mol, CAS 1627580-64-6. It is studied in AMPK signaling, folate-methionine cycle research and mitochondrial-to-nuclear communication in cell lines.
Key Takeaways
- Encoded in mitochondrial, not nuclear, DNA.
- 16 residues: MRWQEMGYIFYPRKLR.
- C101H152N28O22S2, 2174.6 g/mol, CAS 1627580-64-6.
- Available as 10 mg and 40 mg vials.
Identifiers
| Field | Value |
|---|---|
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Other names | Mitochondrial open reading frame of the 12S rRNA type-c |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| CAS number | 1627580-64-6 |
| Form | Lyophilized solid, sealed vial |
A Peptide Encoded in Mitochondrial DNA
Most proteins in a cell are encoded by nuclear DNA. Mitochondria keep a small genome of their own, and short open reading frames within it can encode small peptides. MOTS-c was identified from one of these frames within the 12S rRNA gene. Because its sequence is short and fully defined, identity on a certificate is confirmed directly against the 16-residue sequence.
Research Areas
- AMPK activation in cell lines
- Folate-methionine cycle research
- Mitochondrial-to-nuclear signaling
MOTS-c is often compared with SS-31, a synthetic peptide that targets the inner mitochondrial membrane; see SS-31 vs MOTS-c. It is also supplied with NAD+ and SS-31 in the NAD+ + MOTS-c + SS-31 research bundle.
Storage of the Sealed Vial
The compound ships as a lyophilized (freeze-dried) solid in a sealed vial labelled with its lot number. Store sealed vials as stated on the label, protected from light and moisture; see our storage and handling guide for temperature ranges.
Analytical Verification and Documentation
Each lot is tested by Testides, an independent laboratory, for HPLC purity and content, and the certificate is published with its report number so it can be checked against the lab’s record: MOTS-c 10 mg certificate and MOTS-c 40 mg certificate. New to certificates? Read how to read a COA.
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a 16-residue peptide encoded in the mitochondrial 12S rRNA gene, studied in AMPK and cellular-metabolism research.
What is the molecular weight of MOTS-c?
MOTS-c (C101H152N28O22S2) has a molecular weight of 2174.6 g/mol.
What is the CAS number of MOTS-c?
The CAS number of MOTS-c is 1627580-64-6.
What is the sequence of MOTS-c?
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR).
Sold for in-vitro laboratory research only. Not for human or animal use and not for diagnostic or therapeutic procedures. Nothing here describes or suggests use in people.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
