TB-500: Research Overview and Thymosin Beta-4 Origin
Quick Answer
TB-500 is a synthetic peptide matching the actin-binding region of thymosin beta-4, a 43-residue protein found in most cell types. The fragment is usually described as Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ). It is studied in G-actin binding, actin polymerization and cell-migration research.
Key Takeaways
- Fragment of thymosin beta-4, a 43-residue actin-sequestering protein.
- Commonly described as Ac-LKKTETQ, the protein’s actin-binding motif.
- The exact composition sold as “TB-500” varies between suppliers, so check the batch COA for the measured mass.
- Unrelated to Thymosin Alpha-1 despite the similar name.
Identifiers
| Field | Value |
|---|---|
| Sequence (as supplied) | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ) |
| Other names | Thymosin beta-4 fragment |
| Parent protein | Thymosin beta-4 (43 residues) |
| Molecular weight | See the batch COA (measured by mass spectrometry) |
| Form | Lyophilized solid, sealed vial |
Why the Identity Needs Checking
Unlike BPC-157, “TB-500” has no single registry entry: the name has been used for both the short acetylated fragment and longer thymosin beta-4 preparations. That is why the certificate for each lot matters. It reports the measured mass and the HPLC purity for the material actually in the vial.
Research Areas
- G-actin binding and actin polymerization
- Cell migration assays
- Endothelial cell research
It is supplied alone and in the BPC-157 + TB-500 blend, the GHK-Cu + BPC-157 + TB-500 set and the Wolverine stack. See BPC-157 vs TB-500.
Storage of the Sealed Vial
The compound ships as a lyophilized (freeze-dried) solid in a sealed vial labelled with its lot number. Store sealed vials as stated on the label, protected from light and moisture; see our storage and handling guide for temperature ranges.
Analytical Verification and Documentation
Each lot is tested by Testides, an independent laboratory, for HPLC purity and content, and the certificate is published with its report number so it can be checked against the lab’s record: TB-500 5 mg certificate. New to certificates? Read how to read a COA.
Frequently Asked Questions
What is TB-500?
TB-500 is a synthetic peptide matching the actin-binding region of thymosin beta-4, studied in actin-polymerization and cell-migration research.
Is TB-500 the same as thymosin beta-4?
No. Thymosin beta-4 is the full 43-residue protein; TB-500 is a short synthetic fragment of it.
Is TB-500 the same as Thymosin Alpha-1?
No. Thymosin Alpha-1 is a different 28-residue peptide from thymosin fraction 5; the sequences are unrelated.
What is the molecular weight of TB-500?
It depends on the exact preparation, which varies between suppliers; the batch COA reports the measured mass for each lot.
Sold for in-vitro laboratory research only. Not for human or animal use and not for diagnostic or therapeutic procedures. Nothing here describes or suggests use in people.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
